Luke, you suggested this was a one-time issue upgrading to 3.2.60 - well still refuses to run setup in 3.2.70. What do I do now?
This isn't a problem with Emby.
You can fix by following this article: https://msdn.microsoft.com/en-us/library/ee308453.aspx?f=255&MSPPError=-2147217396
Another article with some context: https://superuser.com/questions/1252575/unable-to-install-clickonce-application-due-to-security-settings-windows-10